Universitätsklinikum Tübingen Institut für Medizinische Gene tik und Angewandte Genomik
Postdoc in Computational Genomics
The Genome Informatics group at the Tübingen University Hospital is looking for a highly motivated Postdoctoral Researcher in the field of Computational Genomics and Statistical Genetics to join the German Human Genome Archive (GHGA) project.
As part of the excellence University of Tübingen, University Hospital Tübingen (UKT) is one of the leading university hospitals in Europe contributing to high-performance medicine, research and teaching. The Institute of Medical Genetics and Applied Genomics focuses on the application of Next Generation Sequencing for diagnostics and research of rare genetic diseases and cancer. As part of the Center for Rare Diseases we diagnose more than 4000 patients per year using whole genome sequencing. As part of the Comprehensive Cancer Center and the Molecular Tumor Board close to 1000 tumors are sequenced per year (whole exome and transcriptome) using the broad range of NGS technologies available in our institute (Illumina NovaSeq, Oxford Nanopore PromethION, PacBio Sequel II).
The successful applicant will be involved in the development of novel methods for the analysis of human whole genome sequencing (WGS) data, with a specific focus on long read technologies (Nanopore PromethION, PacBio Sequel II) and clinical samples from rare genetic diseases and cancer patients. More than 600 Nanopore and 500 PacBio whole human genomes and transcriptomes will be available to test newly developed methods, for instance, for genome de novo assembly with haplotype phasing, analysis of repeat expansion diseases, complex structural variant detection, splicing-defects and the detection of somatic mutations in tumor tissues. Within the Genome Analysis work group of GHGA the successful applicant will help to develop standards for long read WGS analysis and a reference pipeline for the analysis of long read data collected by GHGA.
The Genome Informatics group develops novel methods, tools and clinical decision support systems required for highly advanced NGS-based rare disease and tumor diagnostics, monitoring of treatment response (liquid biopsy), immunotherapy response prediction (RNA-seq, single cell RNA-seq), targeted therapy selection and, more generally, for the optimization of human genome and transcriptome studies using the latest sequencing technologies. We offer a stimulating, international work environment, state-of-the-art infrastructure and a competitive postdoctoral salary. Employment will be initially limited to 2 years, with a possibility for extension. Applicants with a strong background (PhD) in computational genomics, next generation sequencing data analysis and programming are invited to send an e-mail with a short motivation letter, CV, list of publications and names of two references to email@example.com. Deadline for applications is August 18, 2022.